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A severe worldwide crisis was initiated by the use of the drug thalidomide, which was used as an antiemetic agent for pregnant women in many countries. In the early 1960s, the use of thalidomide during the first trimester of pregnancy led to teratogenic effects manifested by the birth of infants with severe deformities known as “Phocomelia”. Since then, the concept of 'Safety of Medicines' is the most important aspect for FDA approvals. It plays crucial role in the better outcomes of Mx. Drug-drug interactions are categorized into PD and PK interactions. Many interactions deemed PD are really the exposure-response effects of a PK interaction leading to greater pharmacologic effect.Let's understand the drug safety and commonly encountered drug interactions in everyday practice with Dr. Desai.
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