7 Jul 2025 • In a study of 14,469 patients with non-cystic fibrosis bronchiectasis, underweight individuals had significantly higher 5-year mortality (24.3%) vs. normal BMI (15.3%; HR = 1.83).

In contrast, overweight (16.6%; HR = 0.77) and obese patients (16.8%; HR = 0.79) showed lower mortality. Underweight patients also faced higher risks of pneumonia, mycobacterial infections, ICU care, and ventilator use.

The study suggests a protective effect of higher BMI, highlighting the need for individualized nutritional management.

Source: BMJ Journals | Read Full Story

7 Jul 2025 • In women referred for heavy menstrual bleeding (HMB), nearly 10% had undiagnosed congenital bleeding disorders—mainly von Willebrand disease—with 9.2% showing factor deficiency and 0.7% having severe forms.

Anemia was common: 34.7% had hemoglobin ≤120 g/L, 42.8% had ferritin <15 μg/L, and 72.5% had levels <30 μg/L. Despite a few transfusions, 75.1% required oral iron.

These findings underscore the need for routine bleeding disorder screening in women with HMB.

Source: Obstetrics and Gynecology | Read Full Story

7 Jul 2025 • A population-based study of over 143,000 individuals revealed a significant bidirectional link between vitiligo and melasma.

Vitiligo patients had a 60% higher risk of developing melasma (1.38 vs. 0.88 per 1,000 person-years; adjusted HR = 1.58), while those with melasma had a 30% increased risk of vitiligo (adjusted OR = 1.32).

The findings suggest shared pathophysiologic pathways and support a more integrated approach to diagnosing and managing pigmentary disorders.

Source: IJDVL | Read Full Story

4 Jul 2025 • A new analysis reinforces the value of pulse wave velocity (PWV)—a marker of aortic stiffness—as a predictive tool for cardiovascular (CV) outcomes and mortality in people with diabetes.

Researchers found that for every 1 m/s increase in carotid-femoral PWV (cfPWV), the risk of CV events and all-cause mortality rose by 7% (HR = 1.07).

Diabetic patients with higher cfPWV faced a 71% higher risk of CV events (HR = 1.71) compared to those with lower values.

These findings bolster the case for incorporating PWV assessment into routine CV risk stratification in diabetes care, offering a noninvasive marker that could sharpen clinical forecasting and prevention strategies.

Source: Science Direct | Read Full Story

4 Jul 2025 • In a study of Indian patients undergoing sleep studies, 5.8% were diagnosed with obesity hypoventilation syndrome (OHS), nearly all alongside obstructive sleep apnea (OSA).

OHS prevalence rose with BMI—9% in BMI 30–40 and 20% in those >50 kg/m². Key predictors included female gender (OR = 4.1), BMI ≥ 35 kg/m² (OR = 3.2), and orthopnea (OR = 4.8).

Findings highlight the need for targeted screening in high-risk groups to avoid missed diagnoses.

Source: Nature | Read Full Story

4 Jul 2025 • Larger uterine volume before pregnancy may raise the risk of preterm birth in women with adenomyosis, according to a retrospective cohort study. Among singleton pregnancies, those who delivered preterm had significantly greater uterine volumes (median 108.9 cm³ vs. 85.3 cm³).

Each 10 cm³ increase in uterine size raised the odds of preterm birth by 36–40%, with an inflection point of 89.3 cm³.

The association was stronger in focal than diffuse adenomyosis (OR 1.43 vs 1.10). Conditions like preterm premature rupture of membrane (28.1% vs 14.3%), placental malposition (32.6% vs 8.9%), and preeclampsia (13.5% vs 5.2%) were also more frequent in preterm cases.

These findings suggest uterine volume may be a risk marker for early monitoring and intervention in adenomyosis-related pregnancies.

Source: BMC Pregnancy and Childbirth | Read Full Story

4 Jul 2025 • A long-term study of Crohn’s disease patients has shown that developing one extraintestinal manifestation (EIM)—such as oral ulcers, joint pain, or skin lesions—raises the likelihood of developing additional EIMs over time.

Among patients followed for up to 25 years, the prevalence of EIMs rose from 21% at diagnosis to 47% by the end of follow-up.

Oral ulcers commonly co-occurred with other EIMs. Joint involvement and skin lesions were most frequent.

Strong associations were found between common manifestations like peripheral arthritis and others, including axial spondyloarthropathy, ocular involvement, and thromboembolism.

The findings highlight the need for early detection and monitoring of EIM clusters in Crohn’s disease.

Source: Science Reports | Read Full Story

4 Jul 2025 • In children under 8 years with healed nutritional rickets, coronal knee deformities tend to correct spontaneously within a year, reducing the need for surgical intervention.

Younger age was the strongest predictor of successful remodeling, with those ≤8 years showing a significantly lower failure rate (29.9%) compared to those >8 years (87.5%; OR 16.4).

Deformities ≤16.5° for valgum and ≤13° for varum showed higher potential for remodeling. Sex, deformity type, and laterality had no significant impact.

These findings suggest current surgical practices may overtreat cases that would otherwise resolve naturally, encouraging a shift toward conservative management in younger children.

Source: Lippincott Journals | Read Full Story

4 Jul 2025 • A new study highlighted that incorporating autologous platelet-rich plasma (PRP) with temporalis fascia in Type 1 tympanoplasty significantly improved outcomes in patients with inactive mucosal chronic suppurative otitis media.

Patients treated with fascia plus PRP consistently showed higher graft uptake rates and better hearing enhancement (Air-Bone Gap closure) at 1, 3, and 6 months postoperatively compared to those with fascia alone.

No major complications occurred in either group. PRP, rich in growth factors like PDGF and VEGF, offers a biologically active, safe, and cost-effective enhancement to traditional tympanic membrane reconstruction.

Source: Springer Nature Link | Read Full Story

4 Jul 2025 • The International Society for Gynecologic Endoscopy (ISGE) has released evidence-based recommendations to reduce the risk of post-hysterectomy vaginal vault prolapse (PHPV) after hysterectomy for benign uterine conditions. There are four recommendations that are tailored to the severity of prolapse.

For non-prolapsed or stage I cases, suturing the cardinal and uterosacral ligaments is advised. McCall’s culdoplasty is recommended for stage II cases, while sacrospinous ligament fixation (SSLF), sacrocolpopexy (SCP), or alternatives like pectopexy are suitable for stages III and IV. However, SSLF and SCP should be avoided in cases without prolapse.

These measures aim to improve long-term surgical outcomes and prevent post-hysterectomy vaginal vault prolapse.

Source: EJOG | Read Full Story